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However, both intrinsic and acquired mechanisms of resistance to aminoglycosides have occurred. Aminoglycoside resistance among gram-negative organisms can occur through acquisition or upregulation of genes that encode inactivating enzymes or efflux systems. The resistance of gram-negative organisms to aminoglycosides occurs by two major mechanisms: Bacterial production of inactivating enzymes. Methylation of 16S ribosomal RNA. This effect is mediated by an enzyme encoded by the rmtA gene and has been associated with high-level resistance to all parenteral aminoglycosides in current use.
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You will find in this section the latest medical thoughts expressed by the experts themselves which we feel are of national importance to all folks. No opinions expressed were written by this civilian editor. Note - FDA is a patriotic institution. FDA announces comprehensive regulatory plan to shift trajectory of tobacco-related disease, death The U. Food and Drug Administration today announced a new comprehensive plan for tobacco and nicotine regulation that will serve as a multi-year roadmap to better protect kids and significantly reduce tobacco-related disease and death. The goal is to ensure that the FDA has the proper scientific and regulatory foundation to efficiently and effectively implement the Family Smoking Prevention and Tobacco Control Act.
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